In The Rome Affair, a Chicago society couple rides a roller coaster of infidelity, blackmail and murder. Rachel Blakely and her husband, Dr. Nick Blakely, have been dealing with marital issues due to Nick’s affair. While away on vacation with her best friend, Rachel commits her own act of infidelity with an intriguing Italian artist. The only one who knows about her affair is her travel companion and best friend, Kit. Upon returning to the states, Rachel goes back to her well-heeled lifestyle while her friend Kit’s life—and mental state—begin to unravel. Kit decides to blackmail her best friend. In trying to keep her Rome affair a secret from her husband, Rachel goes to great lengths both emotionally and financially. The blackmail continues to increase and Rachel begins to lose control of her perfect life.